Management of Gait Impairments in Chronic Unilateral Upper Motor Neuron Lesions

Finger tapping impairments are highly sensitive for evaluating upper motor neuron lesions

BACKGROUND Identifying highly sensitive and reliable neurological exam components are crucial in recognizing clinical deficiencies. This study aimed to investigate finger tapping performance differences between patients with CNS demyelinating lesions and healthy control subjects. METHODS Twenty-three patients with multiple sclerosis or clinically isolated syndrome with infratentorial and/or c...

Temporal Motor Coordination in the Ankle Joint Following Upper Motor Neuron Lesions

[Purpose] We compared ankle temporal motor coordination between stroke, spinal disease and healthy elderly groups, and investigated the relationship between motor impairments and gait speed. [Subjects] Twenty-four patients with stroke, 19 post-operative spinal disease patients and 17 healthy elderly subjects participated. [Methods] Ankle temporal motor coordination of the three groups was asses...

Gender difference in motor impairments induced by chronic administration of vinblastine

Objective(s):Neurotoxicity of anticancer drugs complicates treatment of cancer patients. Vinblastine (VBL) is reported to induce motor and cognitive impairments in patients receiving chronic low-dose regimen. Materials and Methods: The effects of VBL treatment on motor, learning and memory functions of male and female Wistar rats were studied by behavioral related tests. Animals were given chro...

NEUROPHYSIOLOGIC SIGNS OF LOWER MOTOR NEURON IMPAIRMENT FOLLOWING LESIONS OF THE UPPER ONES Ph.D. Thesis

Beta-band intermuscular coherence: a novel biomarker of upper motor neuron dysfunction in motor neuron disease

In motor neuron disease, the focus of therapy is to prevent or slow neuronal degeneration with neuroprotective pharmacological agents; early diagnosis and treatment are thus essential. Incorporation of needle electromyographic evidence of lower motor neuron degeneration into diagnostic criteria has undoubtedly advanced diagnosis, but even earlier diagnosis might be possible by including tests o...